New Research Reveals Link Between Allergic Diseases and Bone loss
〜Piezo Channels suggested as a Potential Therapeutic Target〜【Summary】
Individuals suffering from allergic conditions such as asthma and atopic dermatitis are known to have a higher risk of bone fractures. Traditionally, this has been attributed to the long-term use of corticosteroids, which can weaken bone structure. However, new research suggests that allergic inflammation itself may play a direct role in bone loss.
In a collaborative study led by Dr. Wei-Qi Gao and Professor Mizuho Kido from the Faculty of Medicine, in a research team with Professor Takaichi Fukuda (Kumamoto University), Professor Takayuki Tsukuba (Nagasaki University), and Professor Tomoko Kadowaki, researchers investigated bone health in asthma model mice. The team found that asthmatic mice had significantly reduced bone mass compared with healthy controls—even in the absence of steroid treatment.
Further analysis revealed that the expression of Piezo channels, mechanosensitive molecules that act as force sensors, was markedly decreased in the bones of asthmatic mice. Importantly, activating Piezo channels helped suppress bone loss in these mice, suggesting a novel mechanism by which allergic inflammation may impair bone integrity.
Maintaining bone quality and strength is essential for healthy aging and independent living. These findings highlight the importance of managing allergic inflammation not only to alleviate allergic symptoms but also to protect long-term skeletal health. Piezo channels may represent a therapeutic target for preventing bone loss associated with allergic diseases.
Mizuho A. Kido
Professor
Division of Histology and Neuroanatomy, Department of Anatomy and Physiology, Faculty of Medicine, Saga University, Saga, Japan
E-mail：kido@cc.saga-u.ac.jp
Contact for public relations inquiries:
Saga University Medical Public Relations Division
E-mail：hpkoho@mail.admin.saga-u.ac.jp
Kumamoto University Public Relations Strategy Office
E-mail：sos-koho@jimu.kumamoto-u.ac.jp
+81 096-342-3271
Nagasaki University Center for Public Relations Strategy
E-mail：kouhou@ml.nagasaki-u.ac.jp