Over 35 million people are still living with HIV-1 infection, and nearly two million people die of AIDS-related illnesses each year in the world. In addition, among developed countries, our country has been experiencing increased incidences of HIV-1 infection. Thus, HIV/AIDS remains a substantial threat to the global health, and developing an HIV vaccine and therapies to cure HIV/AIDS have still been a global challenge. New program “International Research Center Aiming at the control of AIDS” intends to enhance and expand international research and education core based on the framework of the successfully implemented global COE “Global Education and Research Center Aiming at the Control of AIDS” Program over the five years. To do this, we reorganize our mission to make a substantial effort to research studies leading to the development of (1) new therapies to cure HIV/AIDS and (2) an HIV/AIDS vaccine. Also, in collaboration with the newly reformed Educational Program for Advanced Research in Infectious Diseases and AIDS, this program intends to enhance capacity-building opportunities, and thereby junior-level scientists and graduate students can be self-standing and globally visible. Collectively, we will contribute to constructing a distinguishable platform that fosters leading-edge research and education in HIV/AIDS field through our expanding inter-continental academic/education partnerships.